5734 S Main Street, Joplin, MO 64801

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$600,000
 est. $2,526/mo

Strategically located near Interstate 44 and the Joplin medical corridor, this highly versatile commercial property offers an exceptional opportunity for investors or owner-users seeking scale, accessibility, and adaptive reuse potential. The building features approximately 7,318 square feet with a functional layout that supports a wide range of business models including medical, professional, event, educational, or institutional use. The interior configuration includes large open areas, multiple private rooms or suites, restroom facilities, and a kitchen/breakroom component -- providing immediate usability with minimal reconfiguration required for many operations. The property's proximity to major healthcare facilities makes it particularly attractive for medical offices, outpatient services, therapy providers, or medical storage / equipment users, while interstate access enhances regional convenience for clients, staff, and logistics. This offering presents a rare combination of size, flexibility, and location efficiency in one of Joplin's most commercially desirable growth areas. Buyer to independently verify zoning, permitted uses, and any applicable municipal ordinances.

Directions
heading southeast on I-44 W take exit 6 for mo-86 E towards Racine. turn left on I-44BL/MO-86. Take second exit on roundabout. in 0.6 miles turn right onto Hearnes Blvd. Property is on the right.
City
Joplin
County
Jasper
Property Type
Business Opportunity / Business
Listing Updated
Mar 17, 2026 at 3:03pm
MLS Number
2607257
Property Tax
$3,282
Zoning
$No
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